British Air Force Typhoon FGR4s have operated alongside French aircraft in a combined operation against an hidden munitions depot in Syrian territory operated by the Islamic State group (IS), according to the UK's MoD.
The location, pinpointed through intelligence, was thought to be housing weapons and explosive materials, the announcement noted, and was located in mountains just north of Palmyra in the heart of Syria.
"Our fighter planes utilized laser-guided Paveway IV weapons to strike a several entry passages providing entry to the facility... initial indications suggest the target was engaged successfully," the ministry announced.
There was no sign of any civilian impact in the operation late on Saturday and all the aircraft made a safe return, the MoD added.
The Typhoon FGR4s were supported by a Voyager refuelling tanker.
Daesh - also known as the so-called Islamic State - imposed militant control over large swathes of both Syria and Iraq until 2019.
"This operation underscores the UK's leading role, and determination to stand shoulder to shoulder with our partners, to eradicate any resurgence of Daesh and their violent and radical beliefs in the region," Britain's Defence Chief John Healey said.
RAF aircraft have carried out surveillance missions over Syria to "deter any efforts to regroup" of IS following its defeat at the climactic battle in Baghuz in the year 2019, the MoD reported.
"I want to thank every member of our armed forces participating in this operation for their skill and their valour," Healey said. "They were among a great many British personnel stationed over the holidays. This mission, to eliminate dangerous terrorists who threaten our safety, highlights how UK forces are prepared to act, all year round, ensuring Britain's security within its borders and influential overseas."
During December, the US military conducted what it described as a "large-scale strike" against IS targets in the country, subsequent to an attack killed two US troops and a civilian linguist in the Palmyra area.
The United Nations reports Daesh still maintains an estimated 5,000 to 7,000 fighters in Iraq and Syria.